Optimal stimulus shapes for neuronal excitation.

An here important problem in neuronal computation is to discern how features of stimuli control the timing of action potentials.One aspect of this problem is to determine how an action potential, or spike, can be elicited with the least energy cost, e.g., a minimal amount of applied current.Here we show in the Hodgkin & Huxley model of the action p

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Integrative Analysis of Machine Learning and Molecule Docking Simulations for Ischemic Stroke Diagnosis and Therapy

Due to the narrow therapeutic window and high mortality of ischemic stroke, it is of great significance to investigate its diagnosis and therapy.We gotrax handlebar employed weighted gene coexpression network analysis (WGCNA) to ascertain gene modules related to stroke and used the maSigPro R package to seek the time-dependent genes in the progress

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Online harassment of Japanese celebrities and influencers

Famous people, such as celebrities and influencers, are harassed online on a daily basis.Online harassment mentally disturbs them and negatively affects society.However, limited studies have been conducted on the online harassment victimization of famous people, and its effects remain unclear.We surveyed Japanese famous people (N = 213), who were c

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Theoretical and methodological principles of energy saving management at construction enterprises: concepts, trends, perspectives

The article analyzes the theoretical and methodological principles of energy saving management, reveals the fragmentation and dissimilarity of the opinions of scientists towards the concepts of energy saving and energy efficiency.Taking into account modern concepts of digital opheliasmuse.com transformation and energy efficient controlling, we have

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